题 目：The plasticity of the autophagic pathway: making autophagosomes big and small

主 讲：Nicholas Ktistakis 博士（英国剑桥巴伯拉罕研究所）

时 间：2026年10月30日（周五）上午10:30-11:30

地 点：琳恩图书馆111报告厅

报告摘要：

Autophagy is a conserved cellular response to nutrient limitation as well as a quality control pathway that eliminates harmful or surplus material from eukaryotic cells. Mediating this response are novel double-membrane vesicles termed autophagosomes whose mechanism of formation exhibits unique characteristics and challenge our understanding of membrane rearrangements during cellular traffic. In my talk I will describe recent and older work from my group that tries to understand how autophagosomes are formed and whether their ultimate function (nutrient limitation vs quality control) as well as their size exhibit mechanistic differences.   

嘉宾简介：

Dr Nicholas Ktistakis is a Senior Group Leader at the Babraham Institute, partner organization of the University of Cambridge. In addition to his research work, he also teaches in the Biochemistry Programme of the University of Cambridge topics related to autophagy and membrane traffic. He is a Molecular Cell Biologist by training interested in autophagy and ageing.

Dr Ktistakis is the Chief Co-Editor (with Professor Dan Klionsky) of the Journal Autophagy and is a co-founder and member of the advisory board of AUTOMERA, a biotechnology company based in Singapore and funded by Singapore and the US to identify novel drugs that use autophagy to degrade harmful cellular material.