题 目：囊泡运输：新规则与新类型

主 讲：贾大 教授（四川大学华西第二医院‌）

时 间：2025年11月3日(周一) 下午16:10-17:30

地 点：琳恩图书馆111报告厅

报告简介：

Vesicle trafficking plays a vital role in maintaining cellular homeostasis by regulating the localization of various intracellular components in eukaryotic cells. Dysregulation of vesicle trafficking gives rise to a spectrum of disorders, including neurological, respiratory, immune, and metabolic disorders. The process of vesicle trafficking involves a series of interconnected events, including cargo recognition and vesicle formation mediated by protein coats at the donor membrane, movement along the cytoskeleton by coupling to motor proteins, vesicle capture by tethering proteins at the target membrane, and subsequent fusion mediated by SNARE complexes. Cargo recognition primarily occurs through coats and the associated proteins at the donor membrane. However, it remains unclear whether cargoes can also be selected at other stages of vesicle trafficking to further enhance the fidelity of the process. The WDR11-FAM91A1 complex functions downstream of the clathrin-associated AP-1 complex to facilitate protein transport from endosomes to the TGN. Here, we report that WDR11 directly and specifically recognizes a subset of acidic clusters, which we term super acidic clusters (SACs). WDR11 complex assembly and its binding to SAC-containing proteins are indispensable for the trafficking of SAC-containing proteins and proper neuronal development in zebrafish. Our studies thus uncover the first example of cargo proteins being recognized in a sequence-specific manner downstream of a protein coat.

嘉宾简介：

贾大，四川大学华西第二医院、生物治疗国家重点实验室教授，华西第二医院研究院副院长。国家杰青，本科毕业于吉林大学，博士毕业于美国艾莫里大学，2008-2015年在美国西南医学中心/HHMI从事博士后研究。2015年起在四川大学建立细胞器生物学实验室。课题组综合利用细胞生物学、生物化学、蛋白质组学、斑马鱼与小鼠模型等多种手段，来研究细胞器的动态调控、囊泡运输及相关神经与代谢疾病的致病机制，开发治疗手段。共发表SCI论文70余篇，文章被引用7500余次。最近5年，作为通讯作者在Cell、Molecular Cell、Nature metabolism、Nat Struct Mol Biol 、Nature Communications、PNAS、J Cell Biol、STTT、Cell Research等期刊发表研究论文; 并受邀在Nature metabolism、 STTT、 Autophagy等期刊发表评论或者综述。目前担任四川省细胞生物学会常务副理事长、中国生物物理学会膜生物学分会副会长、中国细胞生物学会青年工作委员会副主任、细胞黄浦班（WLLA）召集人等职务。基金委重点、优青、面上等项目二审专家。先后获得美国SER-CAT年度青年科学家奖、美国Cancer Research Institute Fellow 、美国西南医学中心杰出博士后、 中国细胞生物学会科普奖、四川大学唐立新优秀学者奖等荣誉或奖励。