题 目：Molecular Mechanisms of Dendrite Arborization: Insights from C. elegans

主 讲：邹 炜 研究员

时 间：2024年12月3日（周二）上午10:00-11:30

地 点：琳恩图书馆2楼学习书坊 

报告摘要：

Neurons grow cell-type specific dendrite arbors to receive and integrate information, which is critical for neural circuit formation. However, the molecular mechanisms which control dendrite arborization have not been fully elucidated. C. elegans PVD sensory neurons grow highly branched dendrites to innervate both skin and body-wall muscle cells. We have performed large-scale genetic screens to isolate mutants which are defective in PVD dendrite arborization. In my talk, I will introduce two recent studies in the lab. In the first part, we find CHDP-1, a cell cortex-localized protein, functions in the PVD neuron to promote cortical actin assembly, which is critical for proper dendritic development and transport of various types of organelles. Loss of chdp-1 causes defects in neuropeptide secretion and proprioception. Interestingly, these defects could be fully suppressed by further inactivating a protein kinase called SAX-1. In the second part, we find the C. elegans skin cells use an EAT-17-BICD-1-dynein-dependent endocytosis machinery to downregulate SAX-7/L1CAM, a dendrite branching ligand, to inhibit ectopic dendrite arborization in the lateral region of the worm body.

个人简介：

Prof. Wei Zou received his PhD degree from the National Institute of Biological Sciences, Beijing, and then moved to the United States to receive his postdoctoral training at Duke and Stanford. He joined the Institute of Translational Medicine, Zhejiang University as a Principal Investigator in the summer of 2017. He dedicates to the study of molecular mechanisms of neurodevelopment and neurodegeneration, as well as developing novel tools to visualize and manipulate gene transcription in living animals. He has published 30 research papers in professional academic journals, such as Dev Cell, J Cell Biol, Nat Commun and PLoS Genet. Currently, he serves as an editorial board member for European Journal of Neuroscience and BMC Molecular and Cell Biology, and as a junior editor for Journal of Genetics and Genomics.