题 目：Genetic and functional genomic studies of autophagy genes in mouse models of breast cancer and vascular sarcoma 

主 讲：Junlin Guan 教授（辛辛那提大学）

时 间：2026年11月16日（周一）上午10:20-11:30

地 点：琳恩图书馆111报告厅

报告摘要：

Autophagy is a highly conserved cellular process for maintenance of cellular homeostasis, and dysfunction of autophagy is implicated in a variety of diseases including cancer, autoimmune disorders and neurodegenerative diseases. FIP200 (FAK-family Interacting Protein of 200 kDa) was initially identified in my laboratory and subsequently shown to be a component of the ULK1/Atg13/FIP200 complex essential for the induction of autophagy. Our previous studies showed that conditional knockout (cKO) of Fip200 decreased mammary tumor development, growth, and metastasis driven by PyMT oncoprotein, providing the first evidence for a pro-tumorigenesis role for autophagy in animals with intact immune systems. Given the increasing evidence for non-canonical autophagy functions of different autophagy genes, we also took a rigorous genetic approach to generate Fip200-4A mutant knock-in allele that blocks its canonical autophagy function specifically to reveal both autophagy and non-autophagy functions of FIP200 in vivo. In this presentation, I will discuss my laboratory’s studies of the complex roles and mechanisms of FIP200 and other autophagy genes in breast cancer and vascular sarcoma using mouse models of these diseases.

嘉宾简介：

Dr. Jun-Lin Guan is a professor in the Department of Cancer Biology at the University of Cincinnati College of Medicine and served as Chair of the Department from 2013 until 2023. Dr. Guan received his BS from USTC in 1982 and PhD from UCSD in 1987. After postdoctoral training at MIT, Dr. Guan served as a faculty at Cornell University (1991-2006), University of Michigan (2006-2013) and currently University of Cincinnati (2013- ). His research aims to understand the fundamental principles of cell signaling and to determine how the disruption of signaling pathways leads to diseases such as cancer. His laboratory has made seminal contributions in two areas of basic cancer research, namely, integrin signaling and autophagy in cancer development and progression. Dr. Guan was editor of Signaling Through Cell Adhesion Molecules (1999) and Cell Migration: Developmental Methods and Protocols (2005) and is the author of more than 250 scientific papers (H-index 87). Dr. Guan has received several awards, including the Kuo Mu-Rao Award (1982), AHA Established Investigator Award (1998), and was elected as an AAAS fellow in 2011.