题 目："Psychic" stem cells connect cell-fate specification to neurodegeneration later in life

主 讲：Zhong Weimin 教授（耶鲁大学）

时 间：2026年9月22日（周二）下午16:20-17:30

地 点：琳恩图书馆111报告厅

报告摘要：

My laboratory studies how neurons in the mammalian neocortex are generated during embryonic development. We study how neural stem cells (1) use Numb-mediated asymmetric cell division to balance the competing needs of self-renewal and differentiation and (2) are temporally patterned to sequentially produce layer-specific neurons by changing neurogenic competence as neurogenesis progresses. Current research combines studies using mice and Drosophila to delineate how cell cycle phases are coupled to molecular mechanisms that enable neural stem cells to specify fates, control number and count time during neurogenesis. We are further examining whether minor defects in the initial specification of neurons during embryogenesis affect their subsequent maintenance to cause neurodegenerative diseases, including AD, ALS/FTD, PD and HD, later in life.

嘉宾简介：

Weimin Zhong, Ph.D., is an Associate Professor in the Department of Molecular, Cellular and Developmental Biology at Yale University. He completed his premedical studies in Biology at Peking University and received his M.D. from Peking Union Medical College. He then earned his Ph.D. in Molecular Cell Biology from The Rockefeller University and completed postdoctoral training in Developmental Neurobiology at the University of California, San Francisco. Current research combines studies using mice and Drosophila to delineate how cell cycle phases are coupled to molecular mechanisms that enable neural stem cells to specify fates, control number and count time during neurogenesis. Dr. Zhong has published extensively in leading journals such as including research in PNAS, Developmental Cell, eLife, Development, and Cold Spring Harbor Perspectives in Biology.