题 目：Reimagining Psychiatric Drug Discovery

主 讲：Jen Q. Pan 教授（Broad Institute博德研究所）

时 间：2025年11月28日(周五)下午16:00-17:30 

地 点：琳恩图书馆111报告厅

摘要：

Psychiatric disorders impose a profound burden on individuals and societies worldwide. Conditions such as schizophrenia and bipolar disorder are chronic, severe, and disabling, affecting 1–3% of the global population, yet current treatments remain limited in both efficacy and tolerability. Developing the next generation of therapeutics will require a strategy that moves beyond symptomatic modulation and instead anchors discovery in human biology—integrating genetic risk, molecular biomarkers, neural circuit function, and cellular mechanisms. Such a strategy demands two key components: (1) Biomarkers that capture disease-relevant biology and enable patient stratification, target engagement, and early readouts of therapeutic response; and (2) Mechanistic insight into the molecular and cellular pathways implicated by emerging human genetic data, including risk variants that converge on synaptic signaling, immune–brain interactions, and sleep–circadian regulation. In this talk, I will outline a roadmap for advancing therapeutic discovery in psychiatric disorders grounded in these principles, and present two examples of genetics-informed discovery programs in preclinical models.

个人简介：

Jen Q. Pan is an Institute Scientist at the Broad Institute of MIT and Harvard and the Director of Translational Neurobiology at the Stanley Center for Psychiatric Research. Her work focuses on the mechanism of psychiatric disorders and genes implicated in psychiatric illnesses, using molecular, cellular, and electrophysiological approaches in both in vitro and in vivo systems.

Dr. Pan has led two drug discovery programs that have been licensed to major pharmaceutical companies, and the Global Research Initiative of Neurophysiology of Schizophrenia (GRINS), which characterized sleep and wake EEG signatures in psychiatric patients and assessed their potential as translational biomarkers. Dr. Pan founded the ICE-T (Ion Channel Electrophysiology and Technology) initiative at the Broad Institute to accelerate innovation in ion channel modulation.

Dr. Pan received her B.S. in Chemistry from Nanjing University and her Ph.D. in Neuroscience from Brown University. She recent publications have appeared in Nature, Natural Communication, Science Translational Medicine, Biological Psychiatry, Molecular Psychiatry, Neuron, Cell Report.