题 目：Mapping the inner world of cells

主 讲：黄波 教授

时 间：2024年11月7日（周四）上午10:00-11:30

地 点：学习书坊

报告摘要：

Cellular processes are orchestrated by many biomolecules in a spatially and temporally coordinated manner within a tiny volume. To uncover the underlying organizational principles and their functional relevance, we take microscopy visualization as the primary approach to systematically map their spatial localization, temporal dynamics, and activity profiles. By combining small tags engineered from split fluorescence proteins and CRISPR/Cas9-mediated gene editing, we have enabled the creation of the OpenCell library: > 1300 human cell lines with endogenously tagged proteins for both microscopy visualization and biochemical analysis. We have further developed the deep-learning framework to connect cellular images of proteins to their amino acid sequences. 

嘉宾简介：

Dr. Bo Huang is a Professor of Pharmaceutical Chemistry and of Biochemistry and Biophysics (joint) at the University of California, San Francisco, and a Chan Zuckerberg Biohub Investigator. He received his B.S. degree in Chemistry from Peking University, China, in 2001 and Ph. D. degree in Chemistry at Stanford University in 2006. After finishing postdoc work at Harvard University in 2009, he joined UCSF as an Assistant Professor. He was promoted to Associate Professor in 2014 and Professor in 2017. Dr. Huang’s research work encompasses the areas of optical microscopy, bioengineering, biophysics, and cell biology. He has pioneered the development and application of super-resolution microscopy and genome engineering. Dr. Huang has received many awards, including the GE Healthcare and Science Prize for Young Life Scientists, the Searle Scholarship, the Packard Fellowship for Science and Engineering, the NIH Director’s New Innovator Award, the American Society for Cell Biology Young Life Scientist Award, and UCSF Byers Award for Basic Science.