题 目：AEOSINOPHILIC ESOPHAGITIS – AN EMERGING DISEASE 

           Novel insights in the local immunological events in Eosinophilic Esophagitis

主 讲：Frank Redegeld 副教授（《欧洲药理学杂志》的主编）

时 间：2024年10月15日(周二) 上午10:30-11:45

地 点：琳恩图书馆2楼学习书坊 

报告摘要：

Once considered a rare condition, eosinophilic esophagitis (EoE) – a chronic, allergen_x0002_driven disorder of the esophagus – is now one of the most common conditions diagnosed during the evaluation of food impaction in adults. Since the first case description back in 1978, current prevalence has been estimated at 34.2 cases per 100,000 inhabitants in the USA and Europe. A recent study in a Shanghai population showed that esophageal eosinophilia is present in nearly 6.6 % of the general adult population of China, while 0.4 % had signs of EoE. EoE substantially impacts patient’s quality of life because of symptoms, dietary restrictions, and the social and psychological implications of living with food-related illness. Current treatment options can be effective but may not provide long-term disease control for all patients due to differences in disease endotype. Esophageal epithelial barrier dysfunction is an important feature of EoE pathogenesis and can be genetically inherited (e.g. genetic variations in calpain-14) or acquired by exposure to environmental toxins (e.g. SLS/SDS) or inflammation (e.g. IL-13). In this seminar, new insights in the local immunological events (e.g activation of mast cells) leading to barrier disruption will be discussed. Further, our studies on the transcriptional effects of local food challenge in EoE patients and tissue explants will be highlighted. 

嘉宾简介：

Frank Redegeld is an Associate Professor at the Division of Pharmacology at the Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, the Netherlands. His research interests involve the molecular mechanisms of cellular activation in chronic inflammatory diseases. Research is centered around a) the molecular mechanisms of activation of mast cells and their role in inflammatory diseases; b) effects of environmental factors (e.g. exogenous and endogenous food compounds) on shaping the immune response and c) discovery of novel biomarkers to monitor disease activity and response to treatment. In previous years, he have unraveled a novel pathway of antigen-specific activation of mast cells via immunoglobulin free light chains. We have shown this pathway may be involved in preclinical models for non-atopic diseases such as upper and lower airway diseases (rhinitis, chronic rhinosinusitis, asthma, COPD, IPF and HP), food allergy, rheumatoid arthritis, IBD, and cancer. Current projects focus on the local immune events in eosinophilic esophagitis.