Topic: The Role of Reversible Protein Phosphorylation in Synaptic (Dys)function and Neurodevelopmental Disorders

Speaker: Principal Investigator Houhui Xia

Time: 16:00-17:30 PM, 26 June (Wednesday), 2024

Venue: Room 111, Lynn Library

Introduction：

Dr. Xia received his Bachelor and Master degrees in physics from Beijing University and University of Minnesota, respectively before he obtained his PhD degree in molecular and cell biology from the University of California at San Francisco. Dr. Xia did his postdoctoral training in neuroscience field at Stanford University with Robert Malenka and then with Dick Tsien before starting his own lab at the Louisiana State University Neuroscience Center at New Orleans. Now he works at the University of Rochester Medical Center.

Abstract：

Protein phosphatase-1 (PP1) and protein phosphatase-2A (PP2A) contribute to more than 90% of serine/threonine dephosphorylation in mammalian cells and negatively regulate synaptic plasticity, learning and memory formation. Dr. Xia’s research focuses on elucidating how PP1 and PP2A are regulated in vivo in synaptic function and memory formation. Dr. Xia lab has made major contributions to PP1 targeting, small molecule (I-2) regulations and different isoforms of PP1 in synaptic plasticity and memory formation. Dr. Xia’s lab is currently investigating how PP1 and PP2A’s human de novo mutations of intellectual disability and epilepsy affect synaptic functions.