题目：蛋白质团聚体在植物免疫中的功能

主讲：胥国勇 教授（武汉大学）

时间：12月14日（周四）11:20-12:20

会议地点：慧园4栋301

报告摘要：

Translational reprogramming is a fundamental layer of immune regulation, but how such a global regulatory mechanism operates remains largely unknown. Here, we perform a genetic screening and identify Arabidopsis HEM1 as a global translational regulator of plant immunity. Loss of HEM1 causes exaggerated cell death to restrict bacterial growth during effector-triggered immunity (ETI). By improving ribosome footprinting, we reveal that the hem1 mutant increases the translation efficiency of pro-death immune genes. We discover that HEM1 contains a plant-specific low complexity domain (LCD) absent from animal homologs. This LCD endows HEM1 with the capability of phase separation in vitro and in vivo. During ETI, HEM1 interacts and condensates with the translation machinery promoted by LCD. CRISPR removal of this LCD causes more ETI cell death. Our results suggest that HEM1 condensation constitutes a brake mechanism of immune activation by controlling the tissue health and disease resistance trade-off during ETI.

个人简介：

武汉大学高等研究院教授、博士生导师，杂交水稻全国重点实验室和湖北省洪山实验室固定成员。2007年获得南开大学生物技术学士学位，2012年获得清华大学生物学博士学位。2012至2013年在清华大学生命学院从事博士后研究；2013至2017年在美国杜克大学从事博士后研究。2018年1月起任武汉大学高等研究院教授。主要从事翻译调控在植物病害防治中的功能研究，研究方向包括蛋白质翻译调控分子机制、基因表达调控、作物抗病育种逻辑设计等。第一和通讯（含共同）作者论文包括Nature，Autophagy，Database，Cell Discovery，Analytical Chemistry，Nature Plants，Cell Host and Microbe等。