题目：Manipulation of plant cellular functions by the bacterial pathogen Ralstonia solanacearum

主讲：Alberto Macho 研究员 （中国科学院分子植物科学卓越创新中心）

时间：11月9日（周四）10:00-10:40

会议地点：慧园4栋301会议室

报告摘要：Plant pathogens cause important losses in crop production every year. Ralstonia solanacearum, the causal agent of the bacterial wilt disease, is one of the most destructive pathogens worldwide. In recent years, it has become evident that R. solanacearum is an excellent model to study plant-pathogen interactions, specially using its type-III secreted effectors (T3Es) as probes to discover new plant functions associated to biotic stress. T3Es have been shown to suppress plant immunity using multiple different strategies, but also to target plant physiological functions that allow bacteria to shape the niche into a favourable environment for bacterial proliferation. Moreover, R. solanacearum is known to employ other unique strategies to evade plant immunity, and therefore it is essential to improve our understanding of these strategies in order to generate sustainable resistance against bacterial wilt disease in crops. In this talk, I will give an overview of the strategies followed in our group aimed at understanding alterations in plant signalling, metabolism, and hormonal balances, mediated by R. solanacearum T3Es, underlying both immune responses and bacterial virulence activities. I will also describe in more detail specific T3E activities targeted to the manipulation of plant metabolism and development in order to support bacterial proliferation.

个人简介： 

RESEARCH EXPERIENCE                                                                                                                                                            

2015 – Present Principal Investigator, Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences, China.

2015 – Present Principal Investigator, Shanghai Center for Plant Stress Biology, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China.

2011 – 2014 Postdoctoral researcher in the group of Prof. Cyril Zipfel, The Sainsbury Laboratory, Norwich, UK.

2010 (5 months)   Postdoctoral researcher in the group of of Prof. Carmen R. Beuzón, Department of Genetics, University of Málaga, Spain.

2008 (3 months)  Visiting researcher under the supervision of Dr. Stéphane Genin, LIPM, Toulouse, France.

2007 (3 months)  Visiting researcher under the supervision of Dr. Pablo Tornero, IBMCP, Valencia, Spain.

2005 – 2010  Graduate student under the supervision of Prof. Carmen R. Beuzón, Department of Genetics, University of Málaga, Spain.

2003 – 2004    Undergraduate student under the supervision of Prof. Carmen R. Beuzón, Department of Genetics, University of Málaga, Spain.

EDUCATION                                             

2005-2010 PhD in Biology (cum laude)

Department of Cell Biology, Genetics and Physiology, Genetics Area, University of Málaga, Spain. Supervisor: Dr Carmen R. Beuzón.

2004-2006 Master’s Degree in Biotechnology

University of Málaga, Spain.

1999-2004 Bachelor of Sciences (Biology)

University of Málaga, Spain.