题 目：From DNA to Life: Decode the noncoding genome

主 讲：沈晓骅 教授

时 间：2023年8月7日下午14:00-15:00

地 点：琳恩图书馆111报告厅

报告摘要:

Life begins with a fertilized egg and undergoes intricate developmental processes, guided by the DNA within the egg that carries essential instructions for shaping the four-dimensional patterning of an organism. The remarkable versatility of our genome enables a single genome to generate hundreds of distinct cell types. However, the specific algorithm governing cell-fate specification remains unknown. Intriguingly, the majority of mammalian genomes (about 98%) consist of noncoding sequences that produce noncoding RNA (ncRNA) transcripts, predominantly residing in the nucleus, defying the traditional dogma of protein synthesis. In this talk, I will discuss the evolving paradigm that has fundamentally transformed our understanding of gene regulation consensus.

嘉宾简介: 

南开大学本科、美国密歇根大学医学院博士、哈佛大学医学院博士后。现为清华大学医学院长聘教授、教育部特聘教授。

致力于非编码核酸调控染色质折叠、转录和细胞核稳态方面的底层规律，探索非编码基因组对基因表达和细胞命运多样性的调控，从独特的视角揭示细胞命运决定的普适性规律。

近年成果包括：1）揭示基因组折叠的基层规律：转座子重复序列（L1 和 B1/Alu）是大尺度染色质三维结构形成的遗传分子基础；2）非编码RNA顺式调控邻近转录和染色质状态是基因表达调控的一种普遍模式；3）RNA和RNA结合蛋白通过相分离反馈调控转录和染色质结构。

曾获教育部特聘教授、国家杰青、求是杰出青年和谈家桢创新奖等奖励，现为《Cell Reports》《EMBO Reports》《Molecular Omics》等期刊编委。