题目：General approach to design of miniprotein binders to arbitrary protein targets

主讲：曹龙兴 教授

时间：2023年5月11日（星期四）15:00-16:30

地点：琳恩图书馆111报告厅

报告摘要：Protein-protein interaction plays a key role in almost all the fundamental life processes, such as virus infection, immune recognition and cell signaling transduction. Designing de novo proteins that could specifically interact with native proteins has shown great potential for drug development and new diagnostic tools. Historically, binder design methds relayed on the information of binding hotspots or binding motifs derived from the complex crystal structures. The ability to design protein binders without using any of the native complex information could broadly expand the horizon of "computationally targetable" protein targets. I will present a method to design de novo protein binders to natural targets where the only information required is the target structure. Successful application of this method to several natural proteins will be shown, including designing picomolar miniprotein inhibitors that could neutralize the SARS-CoV-2 virus. More generally, the approach now enables targeted design of binders to sites of interest on a wide variety of proteins for therapeutic and diagnostic applications.

个人简介：曹龙兴博士，2012年毕业于山东大学生命科学学院，获学士学位。2012-2017年在中国科学院生物化学与细胞生物学研究所攻读博士学位，从事利用结构生物学手段对细胞表面受体进行结构和功能的研究。2017-2021年在华盛顿大学蛋白质设计研究所进行博士后研究，致力于蛋白质设计方法的开发与应用。曹龙兴博士于2021年8月全职加入西湖大学生命科学学院，担任研究员、助理教授（独立PI）一职，继续从事蛋白质设计领域的相关研究。