题 目：Reimagined Proteomes To Precision Medicine Via Long Non-coding RNA.

主 讲：Leonard Lipovich 教授

时 间：2023年3月30日（周四）下午14:00-16:00

地 点：琳恩图书馆111报告厅

嘉宾简介：

Leonard Lipovich, Mohammed Bin Rashid University of Medicine and Health Sciences药学院教授，美国Wayne State University分子医学及遗传学中心兼职教授，2014年获得美国国立卫生研究院(NIH)院长创新奖。致力于临床翻译RNA生物学、基因组学和精确医学及长非编码RNA领域的研究，迄今发表SCI论文80余篇，h-index  40，多篇论文发表在Nature, Nature Genetics, Cell Stem Cell, Molecular Cell等学术期刊。

报告简介：

Two decades ago, the Human Genome Project revealed that 98% of the human genome sequence resided outside of protein-coding genes. In the FANTOM (Functional Annotation of Mammalian cDNA) and ENCODE (Encyclopedia of DNA Elements) Consortia, we helped demonstrate that two-thirds of the ~60,000 human genes do not encode proteins. Long non-coding RNA (lncRNA) genes comprise the most abundant, now still poorly understood, class of the human ncRNA genes. We characterized primate-specific, estrogen-induced oncogenic (and estrogen-repressed tumor-suppressor) lncRNAs in estrogen receptor positive breast cancer. Suppression and rescue, respectively, of these lncRNAs provide new paths toward cancer treatment.  From Genome-Wide Association Studies (GWAS) of type 2 diabetes, we identified and laboratory-validated disease-causal candidate lncRNAs: liver-specific targets for new RNAi-based drugs. As the first to discover, in 2012, rare nonrandom translation of short Open Reading Frames in specific lncRNAs in human cells, we– in 2022 – integrated mass spectrometry with ribosome profiling to show that transcriptional regulation of estrogen-controlled lncRNAs and translational regulation of their ORFs are, surprisingly, discordant. Across these projects, we found that most human lncRNA genes, unlike protein-coding genes, have recent evolutionary origins, lacking conservation between primates and rodents, but nevertheless functional in disease.