时 间：2023年2月9日（周四）下午16:00-17:30

地 点：琳恩图书馆111报告厅

主 讲：胡海岚 研究员（浙江大学医学院神经科学中心执行主任）

题 目：From Pecking Order to Ketamine – Neural mechanisms of social and emotional behaviors

报告摘要/Abstract:

Emotions and social interactions color our lives and shape our behaviors. Using animal models and engineered manipulations, we aim to understand how social and emotional behaviors are encoded in the brain, focusing on the neural circuits underlying dominance hierarchy and depression. This lecture will highlight our recent discoveries on how downward social mobility leads to depression; how ketamine tames depression by blocking burst firing in the brain’s anti-reward center; and, how glia-neuron interaction plays a surprising role in this process. I will also present our recent work on the mechanism underlying the sustained antidepressant activity of ketamine and its brain region specificity. With these results, we hope to illuminate on a more unified theory on ketamine’s mode of action and inspire new treatment strategies for depression.

嘉宾简介: 

胡海岚，浙江大学医学院脑科学与脑医学学院教授、浙江大学教育部脑与脑机融合前沿科学中心主任。致力于研究社会行为和情绪的神经编码和调控机制，特别抑郁症的基础及转化研究。发现了社会竞争中“胜利者效应”的脑机制，揭示了后天的经历经验可以通过重塑神经环路来改变先天的弱势；从分子、细胞和系统等多层面对抑郁症的成因提出了新的阐释，为研发更好、更安全的抗抑郁药物提供了新思路。曾获谈家桢生命科学奖、何梁何利科技进步奖、国际脑研究组织-凯默理神经科学奖、欧莱雅-联合国教科文组织世界杰出女科学家奖等。