The Department of Systems Biology is a dynamic and interdisciplinary research unit dedicated to advancing our understanding of complicated biological systems. We apply multidisciplinary technologies to integrate biological big data, such as genomics and epigenomics, transcriptomics, proteomics and interactomics, to study biological systems. We aim to construct integrated models to explain complex processes in life and apply those models to addressing challenges in human health.
The Department of Systems Biology seeks to establish an integrated research platform for bioinformatics and systems biology research. Our objective is to understand the genetic basis of sophisticated pathological and pathological processes, such as development, neurological disorders, cancer and infectious diseases. We study the underlying regulatory networks and their evolutionary mechanisms in humans and model animals. We develop new techniques to assess, dig out, analyse and manage various biological big data, including genomes, epigenomes, single-cell-omes spatial-omes, proteomes and metabolomes. In addition, by using deep learning and artificial intelligence technologies, we establish multi-dimensional models of regulatory networks to generate prediction systems for complex life processes, enabling comprehensive and accurate interpretation of biomedical big data. This will promote the development of various fields in life sciences and provide a theoretical basis for the practice of precision medicine.
In the next five to ten years, the Department of Systems Biology will establish a core scientific research team comprising 20-25 principal investigators. With further strengthening the research platforms, we are creating a collaborative environment to encourage the true innovation with international impact.
Room309, Building 4, Hui Yuan
0755-88018449
chenw@sustech.edu.cn
Research interest:Systems Biology
Room305, Building 4, Hui Yuan
0755-88010922
wangzf@sustech.edu.cn
Research interest:Mechanisms of RNA alternative splicing; Synthetic biology of RNA binding proteins; RNA functional genomics; Protein translation using circular RNA s; Site-specific RNA editing and related uses by artificially constructed RNA-editing enzymes
Room 303, Research building 1
0755-88018450
andrewh@sustech.edu.cn
Research interest:genomics; stem cells; systems biology;
Room 309, Research Building 1
0755-88015944
liangc@sustech.edu.cn
Research interest:Molecular Cell Biology of Bone, Joint and Tumors
Room 405, Biology Hall
0755-88018412
suny@sustech.edu.cn
Research interest:Tumor Biology; Kidney Diseases;
Room 414, Biology Hall
0755-88018497
chenx9@sustech.edu.cn
Research interest:Systems Biology
Room214, Biology Hall
0755-88018659
zengfx@sustech.edu.cn
Research interest:Structure of RNA/protein complexes; Non-canonical translation regulation; RNA vaccine;
Room 404, Biology Hall
0755-88018669
zhengmz@sustech.edu.cn
Research interest:3D Genomics
Room 416, Research Building 2
0755-88018549
daizw@sustech.edu.cn
Research interest:systems biology; cancer metabolism;
Room 411, Biology Hall
0755-88011109
liangzy@sustech.edu.cn
Research interest:3D genomic research on new technology and application; Mechanism studies of transcriptional regulation; RNA metabolism in functional genomics; ecDNA biology in tumor;
Room310, Building 4, Hui Yuan
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fangl@sustech.edu.cn
Room 313, Building 4, Hui Yuan
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cuihh@sustech.edu.cn
Research interest:Gene Transcription and Epigenetic Regulation; RNA Regulation and Translation Control;
Room 313, Building 4, Hui Yuan
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zhuqh@mail.sustech.edu.cn
Research interest:Cancer evolution and tumor heterogeneity; Transcriptional regulation; Single cell omics;
Room 335, Research Building 1
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fuxk@mail.sustech.edu.cn
Research interest:Mechanistic studies in bone & joint diseases and tumors; Translational medicine in bone & joint diseases and tumors;
Room 418, Biology Hall
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wangl6@sustech.edu.cn
Research interest:Tumor immunity