Speaker: Prof.Haitao LI(Tsinghua University)

Time: 12:30-13:30,Dec. 12,2019

Venue: Library 111 lecture hall

Design a Mark for Epigenetic Regulation


In eukaryotic organisms, access of genetic information is controlled by the “ON” or “OFF” state of chromatin. During the past decades, a remarkable variety of covalent modifications to histones or DNA have been documented. These chemical modifications provide vast indexing potential to the genome, and constitute an additional layer of epigenetic information, referred to as the “histone or epigenetic code” that control the information flow at the chromosomal level. Chromatin modifications are under highly regulated forms of epigenetic control. Eukaryotic cells have evolved with counteracting enzymatic machineries for the installation and removal of given epigenetic marks - distinct histone or DNA modifications. Meanwhile, a wealth of conserved “reader” modules have been created for specific readout of these marks. Here, I report on the molecular basis underlying the recognition and catalysis of hallmark epigenetic modifications by the ever-expanding kingdom of chromatin “readers/modifiers”. The examples presented here highlight how chromatin regulators make use of exquisitely designed modular domains for modification-dependent epigenetic regulation.

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